NH2-C4-NH-Boc

Modify Date: 2024-01-02 20:41:10

NH2-C4-NH-Boc Structure
NH2-C4-NH-Boc structure
Common Name NH2-C4-NH-Boc
CAS Number 68076-36-8 Molecular Weight 188.267
Density 1.0±0.1 g/cm3 Boiling Point 292.9±23.0 °C at 760 mmHg
Molecular Formula C9H20N2O2 Melting Point N/A
MSDS Chinese USA Flash Point 130.9±22.6 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of NH2-C4-NH-Boc


NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name tert-Butyl N-(4-aminobutyl)carbamate
Synonym More Synonyms

 NH2-C4-NH-Boc Biological Activity

Description NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 292.9±23.0 °C at 760 mmHg
Molecular Formula C9H20N2O2
Molecular Weight 188.267
Flash Point 130.9±22.6 °C
Exact Mass 188.152481
PSA 64.35000
LogP 1.06
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.457

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C
Risk Phrases R34
Safety Phrases S26-S36/37/39-S45
RIDADR UN 2735 8/PG 3
WGK Germany 3
Hazard Class 8.0
HS Code 2924199090

 Synthetic Route

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

2-Methyl-2-propanyl (4-aminobutyl)carbamate
BOC-NH(CH2)4NH2 HCL
tert-butyl 4-aminobutylcarbamate
Carbamic acid, N-(4-aminobutyl)-, 1,1-dimethylethyl ester
(4-amino-butyl)-carbamic acid tert-butyl ester
N-(1,1-dimethylethoxycarbonyl)-1,4-butanediamine
BOC-DIAMINOBUTANE HCL
N-Boc-1,4-butanediamine
N-Boc-1,4-butandiamine
N-T-BOC-BUTANDIAMINE HCL
(4-aminobutyl)carbamic acid 1,1-dimethylethyl ester
BUTTPARK 121 6-09
RARECHEM AR PA 0023
tert-ButylN-(4-aminobutyl)carbamate
4-(t-butoxycarbonylamino)butylamine
N-BOC-1,4-DIAMINOBUTANE
AURORA KA-4397
N-(tert-butoxycarbonyl)-1,4-diamino-butane
BOC-DAB HCL
N-tert-Butoxycarbonyl-1,4-butanediamine
MFCD02090802
tert-butyl 4-amino butylcarbamate
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