Mal-C4-NH-Boc

Modify Date: 2024-01-09 19:42:57

Mal-C4-NH-Boc Structure
Mal-C4-NH-Boc structure
Common Name Mal-C4-NH-Boc
CAS Number 124529-64-2 Molecular Weight 296.362
Density 1.1±0.1 g/cm3 Boiling Point 445.8±28.0 °C at 760 mmHg
Molecular Formula C15H24N2O4 Melting Point N/A
MSDS N/A Flash Point 223.4±24.0 °C

 Use of Mal-C4-NH-Boc


Mal-C4-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl [6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl]carbamate
Synonym More Synonyms

 Mal-C4-NH-Boc Biological Activity

Description Mal-C4-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 445.8±28.0 °C at 760 mmHg
Molecular Formula C15H24N2O4
Molecular Weight 296.362
Flash Point 223.4±24.0 °C
Exact Mass 296.173615
LogP 2.64
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.503

 Synonyms

2-Methyl-2-propanyl [6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl]carbamate
MFCD22683316
Carbamic acid, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)hexyl]-, 1,1-dimethylethyl ester
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