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180851-50-7

180851-50-7 structure
180851-50-7 structure
  • Name: Tos-O-C4-NH-Boc
  • Chemical Name: 4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl 4-methylbenzenesulfonate
  • CAS Number: 180851-50-7
  • Molecular Formula: C16H25NO5S
  • Molecular Weight: 343.43800
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-01-15 22:57:59
  • Modify Date: 2024-01-16 19:12:38
  • Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250)[1].

Name 4-[(2-methylpropan-2-yl)oxycarbonylamino]butyl 4-methylbenzenesulfonate
Synonyms Toluene-4-sulfonic acid 4-tert-butoxy-carbonylamino-butyl ester
Description Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250)[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.

Molecular Formula C16H25NO5S
Molecular Weight 343.43800
Exact Mass 343.14500
PSA 93.57000
LogP 4.29040