124529-64-2

124529-64-2 structure

Name: Mal-C4-NH-Boc
Chemical Name: 2-Methyl-2-propanyl [6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl]carbamate
CAS Number: 124529-64-2
Molecular Formula: C₁₅H₂₄N₂O₄
Molecular Weight: 296.362
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-19 20:55:56
Modify Date: 2024-01-09 19:42:57
Mal-C4-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-Methyl-2-propanyl [6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl]carbamate
Synonyms	2-Methyl-2-propanyl [6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl]carbamate MFCD22683316 Carbamic acid, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)hexyl]-, 1,1-dimethylethyl ester

Description	Mal-C4-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562