Mal-NH-Boc
Mal-NH-Boc structure
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Common Name | Mal-NH-Boc | ||
|---|---|---|---|---|
| CAS Number | 134272-63-2 | Molecular Weight | 240.25600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H16N2O4 | Melting Point | 110-115 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mal-NH-BocMal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | tert-butyl N-[2-(2,5-dioxopyrrol-1-yl)ethyl]carbamate |
|---|---|
| Synonym | More Synonyms |
| Description | Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 110-115 °C |
|---|---|
| Molecular Formula | C11H16N2O4 |
| Molecular Weight | 240.25600 |
| Exact Mass | 240.11100 |
| PSA | 75.71000 |
| LogP | 0.76490 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2925190090 |
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~48%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: Richter, Martin; Chakrabarti, Alokta; Ruttekolk, Ivo R.; Wiesner, Burkhard; Beyermann, Michael; Brock, Roland; Rademann, Joerg Chemistry - A European Journal, 2012 , vol. 18, # 52 p. 16708 - 16715 |
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~%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: US5180816 A1, ; |
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~%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 21 p. 2843 - 2848 |
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~%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 20 p. 2975 - 2982 |
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~81%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: Antczak; Bauvois; Monneret; Florent Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 21 p. 2843 - 2848 |
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~92%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: Boehringer Mannheim GmbH Patent: US5595741 A1, 1997 ; |
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~%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: WO2011/9047 A2, ; Page/Page column 16-17 ; |
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~59%
Mal-NH-Boc CAS#:134272-63-2 |
| Literature: Foley, Timothy L.; Yasgar, Adam; Garcia, Christopher J.; Jadhav, Ajit; Simeonov, Anton; Burkart, Michael D. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 20 p. 4601 - 4606 |
CAS#:125923-10-6| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
| [2-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER |
| N-(2-((tert-butoxycarbonyl)amino)ethyl)-maleimide |
| N-(tert.-butyloxycarbonyl)-2-(N-maleinimido)ethylamine |
| N-Boc-2-Maleimidoethylamine |
| tert-Butyl (2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)carbamate |
| N-BOC-2-malemidoethylamine |
| 1-((N-tert-butoxycarbonyl)-2-aminoethyl)maleimide |
| N-[2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl]-carbamic acid tert-butyl ester |
| 2-(maleimido)ethylcarbamic acid tert-butyl ester |
| N-(2-[(Boc)amino]ethyl)maleimide |