1356497-91-0
1356497-91-0 structure
- Name: ST247
- Chemical Name: 3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl este
- CAS Number: 1356497-91-0
- Molecular Formula: C19H26N2O5S2
- Molecular Weight: 426.550
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
- Create Date: 2018-02-04 05:34:18
- Modify Date: 2024-01-13 15:23:29
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ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1].
| Name | 3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl este |
|---|---|
| Synonyms |
3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
2-Thiophenecarboxylic acid, 3-[[[4-(hexylamino)-2-methoxyphenyl]amino]sulfonyl]-, methyl ester Methyl 3-{[4-(hexylamino)-2-methoxyphenyl]sulfamoyl}-2-thiophenecarboxylate ST247 |
| Description | ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ[1]. |
|---|---|
| Related Catalog | |
| Target |
PPARβ/δ |
| In Vitro | ST247 induces a clearly enhanced interaction of the PPARβ/δ LBD with the SMRT-ID2 peptide, with an EC50 of 10 nM[1]. ST247 down-regulates basal level expression of the peroxisome proliferator responsive element-driven PPARβ/δ target gene ANGPTL4, with an IC50 of 19.1 nM[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 595.0±60.0 °C at 760 mmHg |
| Molecular Formula | C19H26N2O5S2 |
| Molecular Weight | 426.550 |
| Flash Point | 313.6±32.9 °C |
| Exact Mass | 426.128326 |
| LogP | 3.60 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.583 |
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |