Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SP-13786
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: UAMC-1110
Price: $850.0/100mg $1350.0/250mg $2700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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1448440-52-5

1448440-52-5 structure

1448440-52-5 structure

Name: SP-13786
Chemical Name: SP-13786
CAS Number: 1448440-52-5
Molecular Formula: C₁₇H₁₄F₂N₄O₂
Molecular Weight: 344.315
Catalog: Research Areas Cancer
Create Date: 2018-04-14 05:05:49
Modify Date: 2024-01-10 08:10:33
FAP-IN-1 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM; also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.

Name	SP-13786
Synonyms	4-Quinolinecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]- N-{2-[(2S)-2-Cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl}-4-quinolinecarboxamide

Description	FAP-IN-1 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM; also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	IC50: 3.2 nM (FAP), 1.8 μM (PREP)[1]
In Vitro	FAP-IN-1 is also found to have better FAP/PREP selectivity and a very proficient ligand efficiency of 0.34.
In Vivo	FAP-IN-1 is the most extensive and prolonged inhibitior of FAP in the PK studies. No tight binding behavior is observed, and the inhibitor proves to bind reversibly to FAP. Pharmacokinetic evaluation in mice of FAP-IN-1 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo[1].
Animal Admin	Rats: The PK parameters are determined for inhibitors 4, 5, 60 (FAP-IN-1), and 61 in rats. Six male rats are treated for each inhibitor tested, three of which received the compound via a single intravenous (iv) administration at 5 mg/kg. The other three animals are dosed per os (po) at 20 mg/kg. Blood samples are collected at 0.083, 0.25, 0.5, 1, 2, 4, 6, and 24 h after administration. Inhibitor concentrations are determined using UPLC−MS/MS, and pharmacokinetic parameters are calculated using standard algorithms[1].
References	[1]. Jansen K, et al. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP). J Med Chem. 2014 Apr 10;57(7):3053-74.

Density	1.4±0.1 g/cm3
Boiling Point	676.4±55.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₄F₂N₄O₂
Molecular Weight	344.315
Flash Point	362.9±31.5 °C
Exact Mass	344.108490
LogP	0.22
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.621
Storage condition	2-8℃