1962928-21-7
1962928-21-7 structure
- Name: PF CBP1
- Chemical Name: PF-CBP1 hydrochloride
- CAS Number: 1962928-21-7
- Molecular Formula: C29H36N4O3
- Molecular Weight: 488.621
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2018-03-29 23:46:19
- Modify Date: 2024-01-10 20:01:28
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PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain[1].
| Name | PF-CBP1 hydrochloride |
|---|---|
| Synonyms |
5-(3,5-Dimethyl-1,2-oxazol-4-yl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]-1H-benzimidazole
1H-Benzimidazole, 5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-2-[2-(4-propoxyphenyl)ethyl]- |
| Description | PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 673.5±55.0 °C at 760 mmHg |
| Molecular Formula | C29H36N4O3 |
| Molecular Weight | 488.621 |
| Flash Point | 361.1±31.5 °C |
| Exact Mass | 488.278748 |
| LogP | 5.46 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Storage condition | -20℃ |