1391194-64-1

1391194-64-1 structure

Name: (2S)-Octyl-α-hydroxyglutarate
Chemical Name: (2S)-Octyl-α-hydroxyglutarate
CAS Number: 1391194-64-1
Molecular Formula: C₁₃H₂₄O₅
Molecular Weight: 260.327
Catalog: Research Areas Cancer
Create Date: 2018-05-16 23:05:49
Modify Date: 2024-01-10 17:17:34
(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.

Name	(2S)-Octyl-α-hydroxyglutarate
Synonyms	Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2S)- (4S)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid MFCD29045545

Description	(2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Treatment of IDH1-WT HeLa cells with (2S)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells[1].
References	[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).