1581270-11-2

1581270-11-2 structure

Name: RIP2 kinase inhibitor 2
Chemical Name: RIP2 kinase inhibitor 2
CAS Number: 1581270-11-2
Molecular Formula: C₂₁H₂₈N₄O₄S
Molecular Weight: 432.536
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2018-01-17 04:31:49
Modify Date: 2024-01-03 00:55:16
RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.

Name	RIP2 kinase inhibitor 2
Synonyms	4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)- N-(4,5-Dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-6-[(2-methyl-2-propanyl)sulfonyl]-4-quinolinamine

Description	RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Cancer
Target	RIP2 Kinase[1]
In Vitro	RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation[1].
Animal Admin	Rats[1] Rats are orally pre-dosed with the RIP2 kinase inhibitor 2, at doses of 0.016, 0.16 and 1.6 mg/kg (n=8 rats/group), followed by dosing with L18-MDP (50 μg/rat) 0.25 hours after pre-dosing with the compound. The IL8 cytokine levels and percentage levels are calculated as the mean±standard error of the mean (n=8 rats/group).
References	[1]. Linda N. Casillas, et al. Amino-quinolines as kinase inhibitors. PCT Int. Appl. (2014), WO 2014043437 A1 20140320.