778274-97-8
778274-97-8 structure
- Name: Multi-kinase inhibitor 1
- Chemical Name: N-(2-Hydroxyethyl)-4-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide
- CAS Number: 778274-97-8
- Molecular Formula: C20H17F3N4O3
- Molecular Weight: 418.369
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
- Create Date: 2018-03-25 19:00:46
- Modify Date: 2024-01-07 10:31:59
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Multi-kinase inhibitor 1 is a potent multi-kinase inhibitor. Multi-kinase inhibitor 1 has the potential for diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl[1].
| Name | N-(2-Hydroxyethyl)-4-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide |
|---|---|
| Synonyms |
N-(2-Hydroxyethyl)-4-(6-{[4-(trifluoromethoxy)phenyl]amino}-4-pyrimidinyl)benzamide
Benzamide, N-(2-hydroxyethyl)-4-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]- N-(2-hydroxyethyl)-4-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-yl)benzamide |
| Description | Multi-kinase inhibitor 1 is a potent multi-kinase inhibitor. Multi-kinase inhibitor 1 has the potential for diseases or disorders associated with abnormal or deregulated tyrosine kinase activity, particularly diseases associated with the activity of PDGF-R, c-Kit and Bcr-abl[1]. |
|---|---|
| Related Catalog | |
| Target |
PDGFR Bcr-Abl |
| In Vitro | Multi-kinase inhibitor 1 (compound 68) is a potent multi-kinase inhibitor. The protein kinases represent a large family of proteins, which play a central role in the regulation of a wide variety of cellular processes and maintaining control over cellular function. These kinases include receptor tyrosine kinases, such as platelet derived growth factor receptor kinase(PDGF-R), the receptor kinase for stem cell factor, c-Kit, and non-receptor tyrosine kinases, such as the fusion kinase Bcr-abl[1]. |
| References |
[1]. Qiang Ding, et al. Novel compounds and compositions as protein kinase inhibitors. WO2004089286A2. |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 615.9±55.0 °C at 760 mmHg |
| Molecular Formula | C20H17F3N4O3 |
| Molecular Weight | 418.369 |
| Flash Point | 326.3±31.5 °C |
| Exact Mass | 418.125275 |
| LogP | 3.20 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.600 |
| Storage condition | -20℃ |