2803505-57-7
2803505-57-7 structure
- Name: Pim-1 kinase inhibitor 1
- Chemical Name: Pim-1 kinase inhibitor 1
- CAS Number: 2803505-57-7
- Molecular Formula: C19H13N3O3
- Molecular Weight: 331.32
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-10-12 17:32:47
- Modify Date: 2024-04-03 10:29:27
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Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer[1].
| Name | Pim-1 kinase inhibitor 1 |
|---|
| Description | Pim-1 kinase inhibitor 1 is a Pim-1 kinase inhibitor with an IC50 of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
IC50: 0.11 μM (Pim-1 kinase), 10.93 μM (MCF-7), 4.91 μM (CACO), 7.01 μM (HepG-2), 3.41 μM (HCT-116), 27.181 μM (WI-38)[1] |
| In Vitro | Pim-1 kinase inhibitor 1 (0-200 μM; 24 h) shows vitro cytotoxic activity to several cancer cells and affects cell apoptosis[1]. Cell Cytotoxicity Assay[1] Cell Line: MCF-7, CACO, HepG-2, HCT-116 and WI-38 cells Concentration: 0-200 μM Incubation Time: 24 hours Result: Exhibited vitro cytotoxic activity to MCF-7, CACO, HepG-2, HCT-116 and WI-38 cell lines with IC50s of 10.93, 4.91, 7.01, 3.41 and 27.181 μM, respectively. Promoted apoptosis by increasing Casp-3, BAX and Bcl-2 concentration to achieve anti-cancer activity. |
| References |
| Molecular Formula | C19H13N3O3 |
|---|---|
| Molecular Weight | 331.32 |