840461-03-2

840461-03-2 structure

Name: SOD1-Derlin-1 inhibitor-1
Chemical Name: SOD1-Derlin-1 inhibitor-1
CAS Number: 840461-03-2
Molecular Formula: C₁₉H₁₂Br₂N₄OS
Molecular Weight: 504.20
Catalog: Research Areas Neurological Disease
Create Date: 2022-10-10 19:46:32
Modify Date: 2024-09-13 19:26:32
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].

Name	SOD1-Derlin-1 inhibitor-1

Description	SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 7.11 μM (SOD1G93A-Derlin-1 complex)[1]
In Vitro	SOD1-Derlin-1 inhibitor-1 (50 μM; 16 h) inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM[1]. SOD1-Derlin-1 inhibitor-1 (250 nM; 6 h) interacts with SOD1G93A with a Kd value of 81.1 μM[1].
References	[1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.

Molecular Formula	C₁₉H₁₂Br₂N₄OS
Molecular Weight	504.20