177904-00-6
177904-00-6 structure
- Name: PD-159020
- Chemical Name: PD-159020
- CAS Number: 177904-00-6
- Molecular Formula: C32H25NO8
- Molecular Weight: 551.543
- Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
- Create Date: 2018-06-18 04:00:05
- Modify Date: 2024-01-10 15:19:37
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PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively.
| Name | PD-159020 |
|---|---|
| Synonyms |
1H-Indole-2-carboxylic acid, 3-(1,3-benzodioxol-5-yl)-1-(1,3-benzodioxol-5-ylmethyl)-5-methoxy-6-(phenylmethoxy)-
3-(1,3-Benzodioxol-5-yl)-1-(1,3-benzodioxol-5-ylmethyl)-6-(benzyloxy)-5-methoxy-1H-indole-2-carboxylic acid |
| Description | PD-159020 is a non-selective ETA/ETB antagonist, with IC50s of 30 and 50 nM for hETA and hETB, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 30 nM (hETA), 50 nM (hETB)[1] |
| In Vitro | PD-159020 demonstrates excellent inhibition of arachidonic acid release, AAR-B, with an IC50 of 0.23 μM. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 758.3±60.0 °C at 760 mmHg |
| Molecular Formula | C32H25NO8 |
| Molecular Weight | 551.543 |
| Flash Point | 412.4±32.9 °C |
| Exact Mass | 551.158020 |
| LogP | 5.92 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.670 |
| Storage condition | 2-8℃ |