745020-66-0
745020-66-0 structure
- Name: NVX-207
- Chemical Name: NVX-207
- CAS Number: 745020-66-0
- Molecular Formula: C36H59NO6
- Molecular Weight: 601.857
- Catalog: Research Areas Cancer
- Create Date: 2018-06-05 15:09:37
- Modify Date: 2024-01-03 12:42:41
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NVX-207 is a derivative of betulinic acid with anti-cancer activity.
| Name | NVX-207 |
|---|---|
| Synonyms |
2-Amino-3-hydroxy-2-(hydroxymethyl)propyl (3β)-3-acetoxylup-20(29)-en-28-oate
Lup-20(29)-en-28-oic acid, 3-(acetyloxy)-, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl ester, (3β)- |
| Description | NVX-207 is a derivative of betulinic acid with anti-cancer activity. |
|---|---|
| Related Catalog | |
| In Vitro | NVX-207 shows anti-tumour activity (mean IC50 = 3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of poly (ADP-ribose) polymerase (PARP). NVX-207 induces cell death via apoptosis[1]. NVX-207 has a high cytotoxicity with IC50 values ranging from 7.6-8.5 µM, in the three analyzed malignant glioma cell lines. NVX-207 leads to PARP cleavage and to a decrease in Survivin expression levels under normoxic and hypoxic conditions. NVX-207 (20 µM) causes a significantly high rate of necrosis of glioma cell lines[2]. |
| In Vivo | Intravenous application of NVX-207 in mice is well tolerated[1]. |
| Cell Assay | Cytotoxic activities are evaluated using the Sulforhodamine-B (SRB) assay. Exponentially growing cells are seeded into 96-well plates at cell densities to prevent confluence for 96 h. After 24 h, the cells are treated using a dilution series of the compounds for 72 h under normoxic or hypoxic conditions. After treatment, the adherent cells are fixed using 10% TCA at 4°C for 1 h; the cells are washed with ice-cold water and are dyed using 100 µL of 4.4% SRB solution for 10 min. After staining, the plates are washed with 1% acetic acid and air-dried overnight. Three hundred microliters of 20 mM Tris base solution is added, and the absorbance is measured at 540 nm using a 96-well plate reader. The IC50 values indicate the concentrations of the compound that cause 50% cell inhibition. The data are obtained in three independent experiments. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 664.8±55.0 °C at 760 mmHg |
| Molecular Formula | C36H59NO6 |
| Molecular Weight | 601.857 |
| Flash Point | 355.8±31.5 °C |
| Exact Mass | 601.434265 |
| LogP | 9.76 |
| Vapour Pressure | 0.0±4.6 mmHg at 25°C |
| Index of Refraction | 1.553 |
| Storage condition | 2-8℃ |