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  • Product Name: Pyy3-36
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  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao


126339-09-1

126339-09-1 structure
126339-09-1 structure
  • Name: Peptide YY Fragment 3-36 human
  • Chemical Name: Peptide YY (PYY) (3-36), human
  • CAS Number: 126339-09-1
  • Molecular Formula: C176H272N52O54
  • Molecular Weight: 3980.42
  • Catalog: Peptides
  • Create Date: 2018-03-09 06:30:14
  • Modify Date: 2024-01-05 18:18:36
  • Peptide YY (PYY) (3-36), human is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.

Name Peptide YY (PYY) (3-36), human
Synonyms MFCD00165623
Description Peptide YY (PYY) (3-36), human is a gut hormone peptide that acts as a Y2 receptor agonist to reduce appetite.
Related Catalog
Target

Y2 receptor[1]

In Vitro Peptide YY (PYY) (3-36), human is a Y2 receptor agonist, generated via cleaving the first two amino acids at the N terminus of PYY1-36 by enzyme dipeptidyl peptidase-IV (DPP-IV), and can reduces food intake[1].
In Vivo In mice, actinonin significantly prolongs the anorectic effect of PYY3-36 (50 nmol/kg) and maintains higher PYY3-36 plasma levels than treatment with PYY3-36 alone[1].
Animal Admin Mice[1] Mice are divided into four treatment groups and administered an injection (maximum volume, 100 μL, sc) of either: 1) saline (n = 10), 2) phosphoramidon (10 mg/kg) (n = 10), 3) PYY3-36 (50 nmol/kg) (n = 10), or 4) PYY3-36 (50 nmol/kg) and phosphoramidon (10 mg/kg) (n = 10). This dose of phosphoramidon inhibits NEP activity for 4 h. Body weight is measured at 0 and 24 h after injection. Food intake is measured at 1, 2, 3, 4, 8, and 24 h after injection[1].
References

[1]. Addison ML, et al. A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36. Endocrinology. 2011 Dec;152(12):4630-40.

Molecular Formula C176H272N52O54
Molecular Weight 3980.42
Appearance lyophilized powder
Storage condition −20°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3