139401-45-9

139401-45-9 structure

Name: CP-96486
Chemical Name: CP-96486
CAS Number: 139401-45-9
Molecular Formula: C₃₁H₂₃ClN₄O
Molecular Weight: 502.99
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2018-05-21 01:00:21
Modify Date: 2024-01-04 18:09:51
CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.

Name	CP-96486

Description	CP-96486 is a potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Kis of 20 and 24 nM, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology
Target	LTD4:20 nM (Ki) PAF receptor:24 nM (Ki)
In Vitro	CP-96486 (CP-96,486) antagonizes 3H-LTD4 binding to guinea pig lung membranes and 3H-PAF binding to rabbit platelets with Ki's of 20 and 24 nM respectively[1].
In Vivo	CP-96486 (CP-96,486) inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50's of 0.27 and 0.26 mg/kg p.o. respectively[1].
References	[1]. A.Marfat,et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4(LTD4)/platelet activating factor (PAF) receptor antagonists.