Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl)
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Purity: 98.0%
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1835705-57-1

1835705-57-1 structure

1835705-57-1 structure

Name: E3 ligase Ligand-Linker Conjugates 10
Chemical Name: E3 ligase Ligand-Linker Conjugates 10
CAS Number: 1835705-57-1
Molecular Formula: C₃₂H₄₇ClN₄O₆S
Molecular Weight: 651.26
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2018-03-30 22:22:27
Modify Date: 2024-01-16 08:58:37
E3 ligase Ligand-Linker Conjugates 10 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Name	E3 ligase Ligand-Linker Conjugates 10

Description	E3 ligase Ligand-Linker Conjugates 10 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate Research Areas >> Cancer
Target	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro	E3 ligase Ligand-Linker Conjugates 10 uses the VHL ligand[1]. The linker is 6-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 10 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
References	[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

Molecular Formula	C₃₂H₄₇ClN₄O₆S
Molecular Weight	651.26