1835705-59-3

1835705-59-3 structure

Name: E3 ligase Ligand-Linker Conjugates 9
Chemical Name: E3 ligase Ligand-Linker Conjugates 9
CAS Number: 1835705-59-3
Molecular Formula: C₄₀H₆₃ClN₄O₁₀S
Molecular Weight: 827.47
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2018-05-08 15:10:22
Modify Date: 2024-01-03 17:50:51
E3 ligase Ligand-Linker Conjugates 9 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

Name	E3 ligase Ligand-Linker Conjugates 9

Description	E3 ligase Ligand-Linker Conjugates 9 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
Related Catalog	Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate Research Areas >> Cancer
Target	E3 Ligase Ligand-Linker Conjugate[1]
In Vitro	E3 ligase Ligand-Linker Conjugates 9 uses the VHL ligand[1]. The linker is 6-2-2-2-2-2-2. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 9 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
References	[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.