1863117-91-2
1863117-91-2 structure
- Name: Photo-lysine
- Chemical Name: Photo-lysine
- CAS Number: 1863117-91-2
- Molecular Formula:
- Molecular Weight: 172.19
- Catalog: Biochemical Assay Reagents
- Create Date: 2018-03-14 14:09:00
- Modify Date: 2024-01-03 21:09:05
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Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications.
| Name | Photo-lysine |
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| Description | Photo-lysine, a new lysine-based photo-reactive amino acid, captures proteins that bind lysine post-translational modifications. |
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| Related Catalog | |
| In Vitro | Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ‘readers’ and ‘erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins[1]. |
| References |
| Molecular Weight | 172.19 |
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