890819-86-0
890819-86-0 structure
- Name: ML 349
- Chemical Name: ML349
- CAS Number: 890819-86-0
- Molecular Formula: C23H22N2O4S2
- Molecular Weight: 454.56
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
- Create Date: 2018-04-26 20:52:33
- Modify Date: 2024-01-08 20:50:02
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ML349 is a potent and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM.
| Name | ML349 |
|---|
| Description | ML349 is a potent and specific acyl protein thioesterase 2 (APT-2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM. |
|---|---|
| Related Catalog | |
| Target |
Ki: 120 nM (APT-2)[1] IC50: 144 nM (LYPLA2)[2] |
| In Vitro | ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively[1]. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells[3]. |
| Cell Assay | Cells are plated in 96-well plates with a density of 4000 to 8000 cells per well and incubated for 24 h at 37°C with 5% CO2. Then cells are treated with increasing drug (including ML349) concentrations and their combinations. Cell viability is measured with the cell viability assay according to the manufacturer's protocol[3]. |
| References |
| Molecular Formula | C23H22N2O4S2 |
|---|---|
| Molecular Weight | 454.56 |
| Storage condition | 2-8℃ |