1034688-30-6

1034688-30-6 structure

Name: GSK 2018682
Chemical Name: GSK-2018682
CAS Number: 1034688-30-6
Molecular Formula: C₂₂H₂₁ClN₄O₄
Molecular Weight: 440.88
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2018-12-03 21:19:30
Modify Date: 2024-01-03 04:33:31
GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.

Name	GSK-2018682
Synonyms	CPD1224 GSK2018682

Description	GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Inflammation/Immunology
Target	pEC50: 7.7 (S1P1 receptor), 7.2 (S1P5 receptor)[1]
In Vitro	GSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4[1].
References	[1]. Xu J, et al. Safety, pharmacokinetics, pharmacodynamics, and bioavailability of GSK2018682, a sphingosine-1-phosphate receptor modulator, in healthy volunteers. Clin Pharmacol Drug Dev. 2014 May;3(3):170-8.