1025821-33-3

1025821-33-3 structure

Name: GSK 626616
Chemical Name: GSK-626616
CAS Number: 1025821-33-3
Molecular Formula: C₁₈H₁₀Cl₂N₄OS
Molecular Weight: 401.269
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2018-06-22 05:10:36
Modify Date: 2024-01-11 13:37:28
GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia[1].

Name	GSK-626616
Synonyms	GSK-626616 OKY0RM282V (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-1,3-thiazol-4(5H)-one 4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-

Description	GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Target	IC50: 0.7 nM (DYRK3)[1]
References	[1]. Connie L. Erickson-Miller, et al. GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia. Blood 2007 110:510;