1334177-96-6

1334177-96-6 structure

Name: OPSS-PEG8-COOH
Chemical Name: 29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid
CAS Number: 1334177-96-6
Molecular Formula: C₂₇H₄₆N₂O₁₁S₂
Molecular Weight: 638.791
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-16 00:45:01
Modify Date: 2024-02-03 20:05:36
OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid
Synonyms	29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid 4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontan-1-oic acid, 29-oxo-31-(2-pyridinyldithio)-

Description	OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562