862901-87-9

862901-87-9 structure

Name: LT175
Chemical Name: (2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid
CAS Number: 862901-87-9
Molecular Formula: C₂₁H₁₈O₃
Molecular Weight: 318.366
Create Date: 2018-06-16 00:30:15
Modify Date: 2024-04-02 22:02:48
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].

Name	(2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid
Synonyms	Benzenepropanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)- (2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid MFCD28386029 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid

Description	LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
Target	hPPARα:0.22 μM (EC50) mPPARα:0.26 μM (EC50) hPPARγ:0.48 μM (EC50)
In Vivo	LT175 (100 mg/kg/day; orally; for 3 days) induces a significant decrease in body weight (11%) and reduces fasting blood glucose, triglycerides, and free fatty acids. LT175 decreases total plasma cholesterol significantly in diet-induced Insulin-resistant mice (six-week-old C57Bl/6J male mice)[1].
References	[1]. Federica Gilardi, et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-6920.

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310 + P330-P391-P501
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all