1309283-32-6

1309283-32-6 structure

Name: 5-Aminosalicylic acid-d3
Chemical Name: 5-Amino-2-hydroxy(2H3)benzoic acid
CAS Number: 1309283-32-6
Molecular Formula: C₇H₄D₃NO₃
Molecular Weight: 156.154
Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
Create Date: 2018-07-12 13:21:08
Modify Date: 2024-01-02 18:57:37
5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

Name	5-Amino-2-hydroxy(2H3)benzoic acid
Synonyms	Benzoic-2,4,5-d3 acid, 3-amino-6-hydroxy- 5-Amino-2-hydroxy(2H3)benzoic acid

Description	5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> PAK Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> PAK
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.;Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells i