796888-12-5
796888-12-5 structure
- Name: LCH-7749944
- Chemical Name: N-[2-(3-methoxyanilino)-4-quinazolinyl]-N-(tetrahydro-2-furanylmethyl)amine
- CAS Number: 796888-12-5
- Molecular Formula: C20H22N4O2
- Molecular Weight: 350.414
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-07-11 14:13:41
- Modify Date: 2024-01-12 08:46:23
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LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1].
| Name | N-[2-(3-methoxyanilino)-4-quinazolinyl]-N-(tetrahydro-2-furanylmethyl)amine |
|---|---|
| Synonyms |
N2-(3-Methoxyphenyl)-N4-(tetrahydro-2-furanylmethyl)-2,4-quinazolinediamine
2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]- N-[2-(3-methoxyanilino)-4-quinazolinyl]-N-(tetrahydro-2-furanylmethyl)amine |
| Description | LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1]. |
|---|---|
| Related Catalog | |
| Target |
PAK4:14.93 μM (IC50) |
| In Vitro | LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner[1]. LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells[1]. LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase[1]. LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells Concentration: 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM Incubation Time: 24 hours Result: Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. Apoptosis Analysis[1] Cell Line: SGC7901 cells Concentration: 5, 10, 20 μM Incubation Time: 12, 24, 48 hours Result: Induced apoptosis of SGC7901 cells. Cell Cycle Analysis[1] Cell Line: SGC7901 cells Concentration: 5, 10, 20 μM Incubation Time: 12, 24, 48 hours Result: Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. Western Blot Analysis[1] Cell Line: SGC7901 cells Concentration: 5, 10, 20, 30 μM Incubation Time: 24 hours Result: Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 580.0±58.0 °C at 760 mmHg |
| Molecular Formula | C20H22N4O2 |
| Molecular Weight | 350.414 |
| Flash Point | 304.6±32.3 °C |
| Exact Mass | 350.174286 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.680 |