1446282-43-4

1446282-43-4 structure

Name: Bromo-PEG3-azide
Chemical Name: 1-Azido-2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethane
CAS Number: 1446282-43-4
Molecular Formula: C₈H₁₆BrN₃O₃
Molecular Weight: 282.135
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-25 02:05:37
Modify Date: 2024-01-03 20:13:35
Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-Azido-2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethane
Synonyms	Ethane, 1-(2-azidoethoxy)-2-[2-(2-bromoethoxy)ethoxy]- 1-Azido-2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethane Bromo-PEG3-azide Bromo-PEG4-azide 1-Azido-2-(2-[2-(2-bromoethoxy)ethoxy]ethoxy)ethane

Description	Bromo-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562