1783256-96-1
1783256-96-1 structure
- Name: ACT-678689
- Chemical Name: N-(6-Chloro-5-{2-[(5S)-5-(2-fluoro-4-methylphenyl)-2-methyl-7,8-dihydro[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl]-2-oxoethoxy}-2-pyridinyl)methanesulfonamide
- CAS Number: 1783256-96-1
- Molecular Formula: C23H22ClFN6O4S2
- Molecular Weight: 565.040
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Tryptophan Hydroxylase
- Create Date: 2018-06-07 19:24:37
- Modify Date: 2024-01-12 15:23:01
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ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
| Name | N-(6-Chloro-5-{2-[(5S)-5-(2-fluoro-4-methylphenyl)-2-methyl-7,8-dihydro[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl]-2-oxoethoxy}-2-pyridinyl)methanesulfonamide |
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| Synonyms |
N-(6-Chloro-5-{2-[(5S)-5-(2-fluoro-4-methylphenyl)-2-methyl-7,8-dihydro[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl]-2-oxoethoxy}-2-pyridinyl)methanesulfonamide
Methanesulfonamide, N-[6-chloro-5-[2-[(5S)-5-(2-fluoro-4-methylphenyl)-7,8-dihydro-2-methyl-1,3,4-thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl]-2-oxoethoxy]-2-pyridinyl]- |
| Description | ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 8 nM (TPH)[1] |
| In Vitro | TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1]. |
| References |
[1]. Daniel Bur, et al. Tricyclic piperidine compounds. WO2015075023A1. |
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C23H22ClFN6O4S2 |
| Molecular Weight | 565.040 |
| Exact Mass | 564.081665 |
| LogP | 2.15 |
| Index of Refraction | 1.734 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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