1325559-30-5

1325559-30-5 structure

Name: FlufenaMic acid-13C6
Chemical Name: FlufenaMic acid-13C6
CAS Number: 1325559-30-5
Molecular Formula: C₈₁₃C₆H₁₀F₃NO₂
Molecular Weight: 287.186
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-12-25 12:48:25
Modify Date: 2024-01-09 12:31:53
Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

Name	FlufenaMic acid-13C6
Synonyms	2-{[3-(Trifluoromethyl)phenyl]amino}(13C6)benzoic acid MFCD20036276 Flufenamic acid-(benzoic ring-13C6) 2-(3-Trifluoromethylphenylamino)benzoic-13C6 acid Benzoic-1,2,3,4,5,6-13C6 acid, 2-[[3-(trifluoromethyl)phenyl]amino]-

Description	Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Epigenetics >> AMPK Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> PI3K/Akt/mTOR >> AMPK Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84. [3]. Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104. [4]. Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100. [5]. Pobbati AV, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015;23(11):2076-2086.

Density	1.4±0.1 g/cm3
Molecular Formula	C₈₁₃C₆H₁₀F₃NO₂
Molecular Weight	287.186
Exact Mass	287.086487
Index of Refraction	1.585

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H315-H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	38-41
Safety Phrases	26-39
RIDADR	NONH for all modes of transport

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