1325559-33-8

1325559-33-8 structure

Name: NifluMic acid-13C6
Chemical Name: NifluMic acid-13C6
CAS Number: 1325559-33-8
Molecular Formula: C₇₁₃C₆H₉F₃N₂O₂
Molecular Weight: 288.174
Catalog: analytical chemistry Standard Analytical standard
Create Date: 2018-12-18 17:32:45
Modify Date: 2024-01-13 22:24:19
Niflumic acid-13C6 is the 13C6 labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

Name	NifluMic acid-13C6
Synonyms	3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl-1,2,3,4,5,6-13C6]amino]- MFCD19704813 Niflumic acid-(phenyl-13C6) 2-(3-Trifluoromethylphenyl-13C6-amino)nicotinic acid 2-{[3-(Trifluoromethyl)(13C6)phenyl]amino}nicotinic acid

Description	Niflumic acid-13C6 is the 13C6 labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Inflammation/Immunology
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. [2]. Criddle, D.N., et al., Inhibitory action of niflumic acid on noradrenaline- and 5-hydroxytryptamine-induced pressor responses in the isolated mesenteric vascular bed of the rat. Br J Pharmacol, 1997. 120(5): p. 813-8. [3]. Jabeen, T., et al., Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr, 2005. 61(Pt 12): p. 1579-86. [4]. Picollo, A., et al., Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels. J Membr Biol, 2007. 216(2-3): p. 73-82.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport