175556-12-4

175556-12-4 structure

Name: RO 46-8443
Chemical Name: Ro 46-8443
CAS Number: 175556-12-4
Molecular Formula: C₃₁H₃₅N₃O₈S
Molecular Weight: 609.690
Catalog: Signaling Pathways GPCR/G Protein Endothelin Receptor
Create Date: 2018-12-10 18:52:36
Modify Date: 2024-04-05 08:23:34
Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM)[1][2].

Name	Ro 46-8443
Synonyms	Ro 46-8443 MFCD00946586 Benzenesulfonamide, N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)- N-{6-[(2R)-2,3-Dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl}-4-(2-methyl-2-propanyl)benzenesulfonamide

Description	Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETB:34-69 nM (IC50) ETA:6800 nM (IC50)
References	[1]. Breu V, et al. In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ETB receptor. FEBS Lett. 1996;383(1-2):37-41. [2]. Clozel M, et al. The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443. FEBS Lett. 1996;383(1-2):42-45.