RO 46-8443

Modify Date: 2024-04-05 08:23:34

RO 46-8443 structure	Common Name	RO 46-8443
	CAS Number	175556-12-4	Molecular Weight	609.690
	Density	1.3±0.1 g/cm3	Boiling Point	683.1±65.0 °C at 760 mmHg
	Molecular Formula	C₃₁H₃₅N₃O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	367.0±34.3 °C

Use of RO 46-8443

Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM)[1][2].

Name	Ro 46-8443
Synonym	More Synonyms

Description	Ro 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. Ro 46-8443 displays an at least 100-fold selectivity for ETB (IC50: 34-69 nM) over ETA receptors (IC50: 6800 nM)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETB:34-69 nM (IC50) ETA:6800 nM (IC50)
References	[1]. Breu V, et al. In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ETB receptor. FEBS Lett. 1996;383(1-2):37-41. [2]. Clozel M, et al. The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443. FEBS Lett. 1996;383(1-2):42-45.

Density	1.3±0.1 g/cm3
Boiling Point	683.1±65.0 °C at 760 mmHg
Molecular Formula	C₃₁H₃₅N₃O₈S
Molecular Weight	609.690
Flash Point	367.0±34.3 °C
Exact Mass	609.214478
LogP	3.22
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.602
Storage condition	2-8°C

Ro 46-8443

MFCD00946586

Benzenesulfonamide, N-[6-[(2R)-2,3-dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl]-4-(1,1-dimethylethyl)-

N-{6-[(2R)-2,3-Dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl}-4-(2-methyl-2-propanyl)benzenesulfonamide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: RO 46-8443
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: RO 46-8443
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: RO 46-8443
Price: $2450.0/1g $650.0/100mg $1200.0/250mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥1000/5 mg

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