1807512-43-1

1807512-43-1 structure

Name: Dde Biotin-PEG4-DBCO
Chemical Name: Dde Biotin-PEG4-DBCO
CAS Number: 1807512-43-1
Molecular Formula: C₄₇H₆₁N₅O₉S
Molecular Weight: 872.080
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-12 13:14:40
Modify Date: 2024-01-10 09:32:13
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Dde Biotin-PEG4-DBCO
Synonyms	1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)- MFCD28505548 N-[19-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Description	Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562