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1807540-84-6

1807540-84-6 structure
1807540-84-6 structure
  • Name: Mal-amido-PEG4-TFP ester
  • Chemical Name: Mal-amido-PEG4-TFP ester
  • CAS Number: 1807540-84-6
  • Molecular Formula: C24H28F4N2O9
  • Molecular Weight: 564.481
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-06-08 05:09:25
  • Modify Date: 2024-01-30 10:21:02
  • Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Mal-amido-PEG4-TFP ester
Synonyms MAL-AMIDO-PEG4-TFP ESTER
Description Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.4±0.1 g/cm3
Boiling Point 686.7±55.0 °C at 760 mmHg
Molecular Formula C24H28F4N2O9
Molecular Weight 564.481
Flash Point 369.1±31.5 °C
Exact Mass 564.173096
LogP 0.39
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.507