Mal-amido-PEG4-TFP ester

Modify Date: 2024-01-30 10:21:02

Mal-amido-PEG4-TFP ester Structure
Mal-amido-PEG4-TFP ester structure
Common Name Mal-amido-PEG4-TFP ester
CAS Number 1807540-84-6 Molecular Weight 564.481
Density 1.4±0.1 g/cm3 Boiling Point 686.7±55.0 °C at 760 mmHg
Molecular Formula C24H28F4N2O9 Melting Point N/A
MSDS N/A Flash Point 369.1±31.5 °C

 Use of Mal-amido-PEG4-TFP ester


Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Mal-amido-PEG4-TFP ester
Synonym More Synonyms

 Mal-amido-PEG4-TFP ester Biological Activity

Description Mal-amido-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 686.7±55.0 °C at 760 mmHg
Molecular Formula C24H28F4N2O9
Molecular Weight 564.481
Flash Point 369.1±31.5 °C
Exact Mass 564.173096
LogP 0.39
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.507

 Synonyms

MAL-AMIDO-PEG4-TFP ESTER
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