Mal-amido-PEG4-acid

Modify Date: 2024-01-17 13:23:50

Mal-amido-PEG4-acid Structure
Mal-amido-PEG4-acid structure
Common Name Mal-amido-PEG4-acid
CAS Number 1263045-16-4 Molecular Weight 416.42300
Density N/A Boiling Point N/A
Molecular Formula C18H28N2O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-amido-PEG4-acid


Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name NHS-PEG4-Maleimide
Synonym More Synonyms

 Mal-amido-PEG4-acid Biological Activity

Description Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C18H28N2O9
Molecular Weight 416.42300
Exact Mass 416.17900
PSA 140.70000
Storage condition 2-8°C

 Synonyms

19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid
Mal-Amido-PEG4-acid
MAL-PEG4-CH2CH2COOH
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