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518044-37-6

518044-37-6 structure
518044-37-6 structure
  • Name: Mal-PEG6-Boc
  • Chemical Name: MAl-PEG6-t-butyl ester
  • CAS Number: 518044-37-6
  • Molecular Formula: C23H39NO10
  • Molecular Weight: 489.556
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-03 18:05:51
  • Modify Date: 2024-01-10 10:49:14
  • Mal-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name MAl-PEG6-t-butyl ester
Synonyms MAL-PEG6-CH2CH2COOTBU
Description Mal-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.1±0.1 g/cm3
Boiling Point 565.2±50.0 °C at 760 mmHg
Molecular Formula C23H39NO10
Molecular Weight 489.556
Flash Point 295.6±30.1 °C
Exact Mass 489.257385
LogP -0.47
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.485