368860-21-3

368860-21-3 structure

Name: Arimoclomol citrate
Chemical Name: N-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy]-1-oxidopyridin-1-ium-3-carboximidoyl chloride,2-hydroxypropane-1,2,3-tricarboxylic acid
CAS Number: 368860-21-3
Molecular Formula: C₂₀H₂₈ClN₃O₁₀
Molecular Weight: 505.90300
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2016-02-12 21:27:48
Modify Date: 2024-01-10 17:06:25
Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].

Name	N-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy]-1-oxidopyridin-1-ium-3-carboximidoyl chloride,2-hydroxypropane-1,2,3-tricarboxylic acid
Synonyms	Arimoclomol citrate [MI] UNII-Q85FFY6179 Arimoclomol citrate 3-Pyridinecarboximidoyl chloride,N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-,1-oxide,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Description	Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	HSP
In Vivo	Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1]. Animal Model: Male Wistar rats weighing 240 to 270 g[1] Dosage: 20 mg/kg Administration: Administered intragastrically, for 5 days Result: Had a protective effect against CCK-induced acute pancreatitis.
References	[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96.