136826-50-1

136826-50-1 structure

Name: 1-Dehydro-[10]-gingerdione
Chemical Name: 1-Dehydro-10-gingerdione
CAS Number: 136826-50-1
Molecular Formula: C₂₁H₃₀O₄
Molecular Weight: 346.461
Catalog: Signaling Pathways NF-κB IKK
Create Date: 2019-01-01 17:16:29
Modify Date: 2024-01-04 13:21:37
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].

Name	1-Dehydro-10-gingerdione
Synonyms	1-Tetradecene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-, (1E)- (1E)-1-(4-Hydroxy-3-methoxyphenyl)-1-tetradecene-3,5-dione

Description	1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS-induced NF-κB transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Research Areas >> Inflammation/Immunology
References	[1]. Hwa Young Lee, et al. 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes. Br J Pharmacol. 2012 Sep;167(1):128-40.