1402453-15-9

1402453-15-9 structure
1402453-15-9 structure
  • Name: ATIC-IN-1
  • Chemical Name: L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro-
  • CAS Number: 1402453-15-9
  • Molecular Formula: C21H33N7O5
  • Molecular Weight: 463.53062
  • Catalog: Research Areas Cancer
  • Create Date: 2018-06-04 09:32:22
  • Modify Date: 2024-02-08 20:19:30
  • ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].

Name L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro-
Description ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
Related Catalog
Target

Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1]

In Vitro ATIC-IN-1(10 μM, 50 μM)是一种特异性抑制剂,在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时,表现出非特异性聚集机制[1]。 ATIC-IN-1(100-500 μM;48 h)抑制 MCF-7 细胞的增殖[1]。 ATIC-IN-1(250 μM;24-72 小时)导致分裂减少而不是导致细胞死亡增加[1]。 Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 100 μM, 250 μM, 500 μM Incubation Time: 0 h, 24 h, 48 h, and 72 h Result: Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.
References

[1]. Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13(11):1628-34.  

Molecular Formula C21H33N7O5
Molecular Weight 463.53062