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1581248-63-6

1581248-63-6 structure
1581248-63-6 structure
  • Name: Tos-PEG3-CH2COOH
  • Chemical Name: Tos-PEG4-CH2CO2H
  • CAS Number: 1581248-63-6
  • Molecular Formula: C15H22O8S
  • Molecular Weight: 362.395
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-08 10:06:20
  • Modify Date: 2024-01-10 11:37:07
  • Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Tos-PEG4-CH2CO2H
Synonyms MFCD27977516
Acetic acid, 2-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-
{2-[2-(2-{[(4-Methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy}acetic acid
Description Tos-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Density 1.3±0.1 g/cm3
Boiling Point 539.9±45.0 °C at 760 mmHg
Molecular Formula C15H22O8S
Molecular Weight 362.395
Flash Point 280.3±28.7 °C
Exact Mass 362.103546
LogP 0.01
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.518