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1818294-25-5

1818294-25-5 structure
1818294-25-5 structure
  • Name: S-acetyl-PEG6-Tos
  • Chemical Name: S-acetyl-PEG6-Tos
  • CAS Number: 1818294-25-5
  • Molecular Formula: C21H34O9S2
  • Molecular Weight: 494.619
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-03 15:05:55
  • Modify Date: 2024-01-22 11:18:51
  • S-acetyl-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name S-acetyl-PEG6-Tos
Synonyms S-(17-{[(4-Methylphenyl)sulfonyl]oxy}-3,6,9,12,15-pentaoxaheptadec-1-yl) ethanethioate
MFCD22201540
Ethanethioic acid, S-[17-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15-pentaoxaheptadec-1-yl] ester
Description S-acetyl-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.2±0.1 g/cm3
Boiling Point 591.0±50.0 °C at 760 mmHg
Molecular Formula C21H34O9S2
Molecular Weight 494.619
Flash Point 311.2±30.1 °C
Exact Mass 494.164429
LogP 0.69
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.513