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1895916-27-4

1895916-27-4 structure
1895916-27-4 structure
  • Name: Acid-PEG9-NHS ester
  • Chemical Name: Acid-PEG9-NHS ester
  • CAS Number: 1895916-27-4
  • Molecular Formula: C26H45NO15
  • Molecular Weight: 611.633
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-13 10:58:39
  • Modify Date: 2024-01-04 07:15:39
  • Acid-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Acid-PEG9-NHS ester
Synonyms 31-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-31-oxo-4,7,10,13,16,19,22,25,28-nonaoxahentriacontan-1-oic acid
MFCD28064339
4,7,10,13,16,19,22,25,28-Nonaoxahentriacontan-1-oic acid, 31-[(2,5-dioxo-1-pyrrolidinyl)oxy]-31-oxo-
Acid-dPEG(R)9-NHS ester
Description Acid-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.3±0.1 g/cm3
Boiling Point 685.1±65.0 °C at 760 mmHg
Molecular Formula C26H45NO15
Molecular Weight 611.633
Flash Point 368.1±34.3 °C
Exact Mass 611.278931
LogP -4.86
Vapour Pressure 0.0±4.6 mmHg at 25°C
Index of Refraction 1.503