73634-68-1

73634-68-1 structure

Name: [D-Trp11]-Neurotensin
Chemical Name: PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
CAS Number: 73634-68-1
Molecular Formula: C₈₀H₁₂₂N₂₂O₁₉
Molecular Weight: 1695.96
Catalog: Signaling Pathways GPCR/G Protein Neurotensin Receptor
Create Date: 2018-07-03 16:39:14
Modify Date: 2024-01-04 09:08:12
[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].

Name	PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU-OH
Synonyms	(D-TRP11)-NEUROTENSIN

Description	[D-Trp11]-Neurotensin, an analogue of Neurotensin (NT), is a selective antagonist of NT in perfused rat hearts but behaves as a full agonist in guinea pig atria and rat stomach strips. [D-Trp11]-Neurotensin can inhibit NT-induced hypotension[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
Target	Neurotensin Receptor[1]
In Vitro	[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts[1]. [D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts[1].
In Vivo	[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED25 of 122 nmol/kg[2].
References	[1]. Quirion R, et, al. Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue. Eur J Pharmacol. 1980 Feb 8;61(3):309-12. [2]. Quirion R, et, al. Hypotensive effects of centrally and peripherally administered neurotensin and neurotensin derivatives in rats. Neuropeptides. 1981 Jou. 1(4): 253-9.