675103-35-2

675103-35-2 structure

Name: BAY-678 racemate
Chemical Name: BAY-678 racemate
CAS Number: 675103-35-2
Molecular Formula: C₂₀H₁₅F₃N₄O₂
Molecular Weight: 400.35
Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
Create Date: 2019-01-20 02:57:00
Modify Date: 2024-01-08 20:45:54
BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

Name	BAY-678 racemate

Description	BAY-678 racemate is a racemate of BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Elastase Research Areas >> Inflammation/Immunology
References	[1]. von Nussbaum F, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.