1926986-36-8
1926986-36-8 structure
- Name: GNE-371
- Chemical Name: GNE-371
- CAS Number: 1926986-36-8
- Molecular Formula: C24H25N5O3
- Molecular Weight: 431.49
- Catalog: Dye Reagents
- Create Date: 2019-02-10 14:03:35
- Modify Date: 2024-01-10 11:06:18
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GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).
| Name | GNE-371 |
|---|
| Description | GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). |
|---|---|
| Related Catalog | |
| Target |
IC50: 10 nM (TAF1(2))[1]. |
| In Vitro | GNE-371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies[1]. |
| References |
| Molecular Formula | C24H25N5O3 |
|---|---|
| Molecular Weight | 431.49 |