1627902-21-9
1627902-21-9 structure
- Name: JNJ-54175446
- Chemical Name: JNJ-54175446
- CAS Number: 1627902-21-9
- Molecular Formula: C18H13ClF4N6O
- Molecular Weight: 440.78
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel P2X Receptor
- Create Date: 2019-02-09 15:55:20
- Modify Date: 2024-01-05 15:32:08
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JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
| Name | JNJ-54175446 |
|---|
| Description | JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. |
|---|---|
| Related Catalog | |
| Target |
pIC50: 8.46 (hP2X7 receptor), 8.81 (rP2X7 receptor)[1] |
| In Vitro | JNJ-54175446 (Compound 14) is a potent and selective brain penetrant P2X7 antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 and rP2X7, respectively. JNJ-54175446 shows less potent activity against mouse, dog and Macaque P2X7 (pIC50, 7.8, 7.9 and 8.1, respectively)[1]. |
| In Vivo | JNJ-54175446 shows dose-dependent occupancy with the ED50 of 0.46 mg/kg, corresponding to plasma EC50 of 105 ng/mL[1]. |
| References |
| Molecular Formula | C18H13ClF4N6O |
|---|---|
| Molecular Weight | 440.78 |