1629052-78-3
1629052-78-3 structure
- Name: KZR-504
- Chemical Name: KZR-504
- CAS Number: 1629052-78-3
- Molecular Formula: C21H23N3O6
- Molecular Weight: 413.42
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Proteasome
- Create Date: 2019-02-08 11:26:46
- Modify Date: 2024-01-10 12:10:27
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KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively.
| Name | KZR-504 |
|---|
| Description | KZR-504 is a highly selective and orally active inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2), with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 51 nM (LMP2), 4.274 μM (LMP7)[1]. |
| In Vivo | Evaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 (compound 12) is both selective and potent in vivo with >50% target inhibition achieved at >1 mg/kg in all tissues tested except brain[1]. |
| References |
| Molecular Formula | C21H23N3O6 |
|---|---|
| Molecular Weight | 413.42 |