2093388-33-9

2093388-33-9 structure

Name: PROTAC BET degrader-2
Chemical Name: PROTAC BET degrader-2
CAS Number: 2093388-33-9
Molecular Formula: C₄₁H₄₂N₁₀O₆
Molecular Weight: 770.84
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-02-12 18:07:55
Modify Date: 2024-01-13 09:55:37
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.

Name	PROTAC BET degrader-2

Description	PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
Related Catalog	Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain Signaling Pathways >> PROTAC >> PROTAC Research Areas >> Cancer
Target	IC50: 9.6 nM (BET in the RS4;11 leukemia cell line)[1].
In Vitro	PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression[1].
References	[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.